The partnership anywhere between BMD and you will pounds try stronger than between Body mass index and you may BMD

step three.3. Exposure Facts

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Body mass index and pounds were correlated that have BMD, and you can BMC symptoms and most effective Pearson’s relationship coefficients was in fact located between pounds and you can BMC in total cool and you may trochanter countries and you may brand new weakest ones was basically ranging from Body mass index and femoral neck BMC. The brand new correlations ranging from ages and BMD and you may BMC symptoms was negative (Dining table 4).

The age-modified ratio of BMD and BMC type said by Bmi and you can lbs try revealed in the Table 5. Pounds tended to show higher variations in BMD and you may BMC delivery whatsoever the newest read skeletal internet sites versus Body mass index. This was shown by the steeper slope (?) of one’s respective linear regression traces. The best difference between BMD and you will BMC delivery checked in the trochanter BMC followed closely by lumbar BMC for lbs. Lbs is a vital predictor from BMD and you may BMC variation in earlier Iranian guys.

cuatro. Conversation

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The fresh elements in which fatty tissue exerts positive effects to the BMD position commonly completely obvious. Brand new putative procedure value away from fatty tissue for skeletal integrity probably stays in this new character of several adipokines from inside the bone restorations using influence on both formation and you will resorption. Recently, bone could have been felt an hormonal body organ affecting weight manage and you will sugar homoeostasis from the tips regarding bone-derived points such as for example osteocalcin and you will osteopontin [23, 34–36]. The fresh putative crosstalk between lbs in addition to bones comprises an effective homoeostatic opinions system in which adipokines and you may molecules released of the osteoblasts and you will osteoclasts portray the hyperlink of an active bone-adipose axis [34–36]. Obesity is even of BMD by the conversion https://datingranking.net/escort-directory/ process from androgen so you can estrogen , which advances limbs mass in men and women [38, 39] and you may preserves match plasma degrees of insulin and you will controlling issues including insulin-particularly increases foundation-1, leptin, and you can adiponectin . As well, carrying excess fat brings padding towards the hip in case there is a beneficial slide . But not, brand new mechanisms by which all these occurrences occur will still be not sure.